17, Jul 2024
How New Research Could Change the Way We Fight the Opioid Epidemic
Jupiter, FL, July 17, 2024 — New research from a Max Planck Florida Institute for Neuroscience researcher could transform how we understand the way opioids affect the brain. Despite significant discussion surrounding the ongoing opioid crisis, current understanding of how opioids function in the brain is quite limited. This is primarily due to challenges in observing and measuring opioid effects in the brain in real-time. However, a recent technological breakthrough, led by Dr. Lin Tian and her research team and collaborators, recently published in Nature Neuroscience, has overcome these limitations and is set to transform how scientists study opioid signaling in the brain.
What do we know about opioid signaling?
Pharmaceutical opioids, such as morphine and oxycodone, and illicit opioid drugs like heroin, affect the brain and body by binding to opioid receptors on the surface of cells in the nervous system. These receptors normally respond to naturally produced chemicals that are released in your brain, called endogenous opioids, including endorphins, enkephalins, and dynorphins.
Released in response to pleasurable activities such as laughter, sex, and exercise and aversive activities like injury and trauma, these chemicals bind opioid receptors and reduce the ability of neurons to receive and transmit signals. These cellular effects ultimately lead to the cognitive and behavioral effects associated with opioids, including positive feelings, pain relief, and addiction.
Challenges in understanding opioid signaling
Numerous questions remain about how these behavioral effects are caused by opioids and whether it is possible to harness specific opioid properties such as pain relief without undesirable effects, such as addiction. The opioid scientific literature is extensive and has confirmed that targeting the opioid system is of clinical interest – not only for pain management but also, more recently, for the treatment of mental health disorders such as anxiety and depression. Development of therapeutics that can target these health challenges while preventing the tragedy of the current opioid epidemic requires further understanding of the diverse effects of opioids in the brain.
The diversity of opioid effects on the brain is driven by more than 20 different opioid chemicals produced in the brain and more than 500 different synthetic opioids. Most of these different opioids interact with all three types of opioid receptors with different strengths. Their varied effects depend on the concentration of opioid, the specific receptors present and the brain circuits involved.
“Efforts are underway to harness various therapeutic properties of opioids by targeting specific receptor actions and brain circuits to develop more effective and safer therapeutics. However, these efforts have been hampered by our inability to measure diverse opioid signaling in real time in the brain effectively,” said Dr. Tian.
New technology opens door to understanding opioids in brain
Through a massive effort developing and testing over 1,000 variants, Dr. Tian’s team has optimized highly-sensitive biosensors based on the three opioid receptors. These biosensors, originally developed while Tian was at the University of California, Davis, emit fluorescence upon opioid binding to the sensor and turn off when the opioid is no longer there. The biosensors, therefore, serve as a proxy for opioid binding to specific opioid receptors.
Introducing these sensors into the brain of an animal provides a way to visualize opioid signaling across the brain in real-time.
“The power of this new technology is that we now have the tools to understand the natural opioid system in the brain, including how to distinguish between different opioid effects. We can track endogenous opioid release in real-time, triggered by both reward and aversion and see the differences in opioid signaling in different brain circuits.”
Dr. Tian’s team has already been sharing these new tools widely to accelerate the impact this new technology will have on the understanding of opioids.
Citation:
Title: Unlocking opioid neuropeptide dynamics with genetically-encoded biosensors Authors: Chunyang Dong, Raajaram Gowrishankar, Yihan Jin, Xinyi Jenny He, Achla Gupta, Huikun Wang, Nilüfer Sayar Atasoy, Rodolfo Flores-Garcia, Karan Mahe, Nikki Tjahjono, Ruqiang Liang, Aaron Marley, Grace Or Mizuno, Darren Kirin Lo, Qingtao Sun, Jennifer L. Whistler1, Bo Li, Ivone Gomes, Mark Von Zastrow, Hugo A Tejeda, Deniz Atasoy, Lakshmi A Devi, Michael R. Bruchas, Matthew R. Banghart, Lin Tian
Journal: Nature Neuroscience
- 0
- By Rabindra
17, Jul 2024
California Surgeon General Dr. Diana E. Ramos to Speak at Free Online Event ACEs & Teaching Resilience in Early Childhood, Hosted by The Discovery Source
San Diego, CA, July 17, 2024 — On Tuesday, July 23 at 1pm PST, The Discovery Source, publishers of early childhood education resources, will welcome “California’s Doctor,” Dr. Diana E. Ramos, for a special online event focusing on adverse childhood experiences (ACEs), a top priority of the Office of the California Surgeon General. The discussion is part of the company’s “Lunch & Learn” event series, which are free, one-hour sessions designed to provide early childhood communities with practical strategies and resources to enhance mental health wellness and social-emotional support.
“We are thrilled to have the California Surgeon General join us for this vital
discussion on early childhood mental health,” says David Scahill, founder and CEO of The Discovery Source. “Our goal with the Lunch & Learn webinars is to bring professionals in the field together to expand public understanding of the impact of early childhood education and intervention. We are proud to support the California Surgeon General’s prioritization of applying evidence-based solutions to ACEs.”
In addition to the California Surgeon General, the webinar will also be joined by early childhood development specialist Dr. Angela Searcy and Director of Professional Development for The Discover Source and early childhood education specialist Sandy Ampudia, both highly experienced leaders in the field.
Dr. Diana E. Ramos is a renowned public health leader and California’s second Surgeon General and first Latina Surgeon General. Her office continues to demonstrate a tremendous commitment to the mental health and wellbeing of children and families by dedicating considerable resources towards trauma informed care and evidence-based interventions through early childhood education.
Members of the media are invited to attend and encouraged to cover the event in order to raise awareness of these important issues.
17, Jul 2024
Author Jay Clark, Ph.D.’s New Book The Five Principles of Global Teams
Prosper, TX, July 17, 2024 — Jay Clark, Ph.D., who earned a PhD in leadership studies from Carolina University and has been dedicated to practicing, researching, and teaching global leadership for over two decades, has completed his new book, “The Five Principles of Global Teams: Leading Across Boundaries”: a comprehensive guide to navigating the complexities of leading diverse teams in today’s interconnected world.
From his experiences of working in emerging markets around the world, author Jay Clark, Ph.D. developed the Nextgen Global Leaders Program—a program for corporations and nonprofit organizations that are transforming into global companies and need to identify, train, and manage top talents to expand globally. To expand the NGLN, Jay founded Nextgen Global Leaders in Singapore in 2015 to serve Asian organizations in developing global leaders, followed by organizations in the Middle East and the United States.
“‘The Five Principles of Global Teams’ analyzes what makes and breaks leadership styles and activities on the global stage. From small working groups to massive international companies, the principles of global teams can be applied to increase leadership awareness, make course corrections, and increase both productivity and accountability. Contained within are clear and concise examples which can be applied to any business leader willing to take a hard look at what may be holding their team back,” writes author Jay Clark, Ph.D.
17, Jul 2024
Deborah Cassidy Chosen as a Woman of the Month for June 2024 by P.O.W.E.R.
Lakewood Ranch, FL, July 17, 2024 — Deborah Cassidy of Lakewood Ranch, Florida, has been chosen as a Woman of the Month for June 2024 by P.O.W.E.R. (Professional Organization of Women of Excellence Recognized) for her outstanding contributions and achievements in the field of cleaning.
About Deborah Cassidy
Deborah Cassidy is the owner of Clean As A Whistle, a home cleaning service in Bradenton, Florida serving Manatee County and the surrounding areas.
Cassidy started the cleaning service in 2002, after the prestigious accounting firm she was working for laid her off due to corporate closings. Family and friends who knew of her love of both people and house cleaning suggested a cleaning service. Deborah worried that she would not find a client base, but she posted a flyer and quickly built a successful business. The name, “Clean As A Whistle,” was derived from Deborah’s father’s habit of whistling on the job site, making him easy to find.
As a testament to her and her staffs’ commitment to providing clients with excellent service, Clean As A Whistle was a finalist for seven years in a row for the Small Business Award of Manatee County and won in 2018. The company also was honored with the People’s Choice Award- Best Cleaning Company in Bradenton/Sarasota area.
Cassidy makes giving back a priority and Clean As A Whistle is a proud partner of the Cleaning for a Reason Foundation, a nonprofit that offers professional house cleaning services free of charge to help improve the lives and ease the burdens of women undergoing treatment for cancer.
17, Jul 2024
Capri Med Spa Unveils Comprehensive Medical Spa Services in Glendale, CA
Glendale, CA, July 17, 2024 — Capri Med Spa is thrilled to announce the expansion of its premier medical spa services in Glendale, CA. Specializing in a wide range of advanced treatments, Capri Med Spa offers injectables, laser treatments, and various facials to help clients achieve their beauty and wellness goals.
Injectables: Capri Med Spa provides top-of-the-line injectable treatments to enhance and rejuvenate your appearance. The services include:
BOTOX® and Dysport®: Smooth out fine lines and wrinkles for a more youthful look.
Juvéderm® and Restylane®: Fillers for enhancing lips, cheeks, jawline, temples, and nasolabial folds.
KYBELLA®: A non-surgical solution for reducing submental fat (double chin).
Sculptra®: Stimulates collagen production for long-lasting facial volume.
Laser Treatments: Utilizing state-of-the-art technology, Capri Med Spa offers effective laser treatments for various skin concerns:
Laser Hair Removal: Achieve smooth, hair-free skin with advanced laser hair removal services.
IPL Laser Treatments: Improve skin tone and texture, targeting sun damage, age spots, and more.
Facials: Expert estheticians deliver customized facial treatments to address specific skin needs:
Acne Facials: Deep cleansing and targeted treatments to combat acne.
Brightening Facials: Enhance skin radiance and clarity.
Anti-Aging Facials: Reduce signs of aging with advanced techniques and products.
Chemical Peels: Exfoliate and renew the skin for a fresh, youthful glow.
Microdermabrasion: Gently exfoliate to improve skin texture and tone.
Microneedling: Stimulate collagen for smoother, firmer skin.
PRP Facial Treatment: Harness the power of platelet-rich plasma for natural rejuvenation.
Capri Med Spa’s mission is to provide the clients with the highest quality of care and the latest in aesthetic treatments offering a comprehensive range of services to help so the clients look and feel their best.
Capri Med Spa in Glendale, CA, is a leading medical spa offers a wide range of advanced aesthetic treatments. Their services include injectables, fillers, laser and IPL treatments, all designed to help clients achieve their beauty and wellness goals in a serene and professional setting. Capri Med Spa is committed to delivering exceptional results in a luxurious and relaxing environment. Their team of experienced professionals ensures personalized care and customized treatment plans for every client. Even if you are looking for just facials in Glendale, Capri offers a variety of facial services.
17, Jul 2024
Unlocking Growth: The Role of API Security in Business Expansion
Pune, Maharashtra, India In today’s digital landscape, businesses are constantly seeking ways to increase their operations and reach a wider audience. One important tool that can support this growth is API security. API (Application Programming Interface) security plays a vital role in protecting the data and information exchanged between different systems and applications. As companies continue to adopt cloud-based technologies and rely on interconnected systems for seamless operations, the need to protect APIs becomes even more essential. A breach in API security not only compromises customer trust but also exposes the organization to potential financial losses and damage to its reputation. Businesses can confidently explore new partnerships, enter new markets, and innovate with the assurance that their API infrastructure is secure by applying strong security measures such as authentication, authorization, encryption, and monitoring. Ultimately, prioritizing API security not only protects valuable assets but also facilitates sustainable growth and reliability in today’s digital landscape. Businesses can build trust with their customers and partners by securing the APIs, which leads to exponential growth opportunities.
As per a report, over 83% of businesses utilize APIs to increase the return on investment for their digital assets. API integration platforms are increasingly favored for simplifying workflows, linking business applications and systems, and improving operational efficiency and productivity. The Global Application Programming Interface (API) Security market reached a value of USD 1.6 Billion in 2023 and is expected to reach USD 10.7 Billion by 2030 as per the study.
Strengthening Customer Trust
API security is essential for businesses looking to build and maintain trust with their customers. When customers interact with a company’s digital platforms, they expect their data to be protected from cyber threats. Businesses can protect their APIs from unauthorized access and potential breaches by effecting stringent security measures, such as authentication, encryption, and rate limiting. This not only helps in preventing data leaks but also builds confidence among customers that their information is safe and secure. In today’s digital age where cyber threats are constantly advancing, strong API security measures demonstrate a commitment to preserving customer data and maintaining trust. Ultimately, investing in API security not only protects businesses from potential financial losses due to data breaches but also promotes long-term relationships with customers and attracts new ones who value privacy and security.
Facilitating Seamless Integration
In the fast-paced business world, seamless integration of different systems and applications is necessary for efficiency and productivity. API security certifies that these integrations are not only smooth but also secure. Companies can protect their APIs from potential cyber threats and unauthorized access by implementing strong security measures and access control. Businesses can run their operations well and focus on innovation and growth rather than worrying about cyber threats by protecting the APIs from potential vulnerabilities.
Unlocking New Business Opportunities
When businesses prioritize API security, they open doors to new growth opportunities. Secure APIs simplify the process of collaborating with partners for businesses, integrating with third-party vendors, and expanding their offerings to new markets or developers without the fear of data breaches or cyber-attacks. Businesses can tap into new revenue streams and diversify their product and service portfolio, leading to overall growth and profitability by using secure APIs.
Conclusion
In conclusion, API security is a critical component for businesses looking to succeed and expand in today’s digital age. Businesses can build trust with customers, facilitate seamless integrations, and unlock new growth opportunities by prioritizing the security of their APIs. Investing in API security not only protects the business from cyber threats but also leads to sustainable growth and success in the long run.
17, Jul 2024
SGT University Honors The Best of Under Graduate Students at Felicitation Ceremony
17th July 2024 Gurugram, Haryana, India SGT University celebrated the outstanding achievements of its undergraduate students at a Felicitation Ceremony organized by the Scholar’s Council on March 16, 2024. This event recognized the hard work and innovative contributions of the university’s student researchers, who devoted the past year to exploring various cutting-edge concepts.
The Scholar’s Council, a student-centric body focused on nurturing innovative ideas and leadership skills, saw an impressive 600 registrations for the academic year 2023-24, demonstrating the strong commitment of SGT University’s young researchers.
Esteemed guests graced the ceremony, including Prof. Dr. S.C. Malik, Dean of Physical Sciences at Maharshi Dayanand University, Rohtak, as the Chief Guest, and Ms. Jaspreet Kaur, Director of Regulatory Affairs at APIs Centrient Pharmaceuticals, Gurugram, as the Guest of Honor. Dr. Malik delivered a motivating speech, and Ms. Kaur highlighted the critical need for more young researchers in India.
The ceremony showcased the top eight research projects of the 2023-24 session across various faculties, including Allied Health Sciences, Pharmacy, Physiotherapy, Indian Medical System, Agricultural Sciences, Engineering and Technology, Applied and Basic Sciences, and Mass Communication and Media Technology. The winners were honored for their exceptional research contributions, and certificates of participation were awarded to all students who conducted research projects.
These research projects covered a diverse range of innovative topics. In the Medical sciences space, the winners were Rocky Rana, for his project on Synthesis and Characterization of Copper Nanoparticles for Anti-bacterial Purposes; Arshnoor Kaur Naval Bhallar for her project on Mantle Cell Lymphoma and Orphan Drugs; and Anjali Shubham Ashish for her project on Early Neural Changes in Asymptomatic Floor Cleaners.
In the non-medical sciences space, the winners were Shubhangi, Prerna, Aakriti, Joginder, and Nakul Kumar for their project on nutrient composition of soil of different regions of Gurugram; Raveen for his project on Deep learning human activity detection model; and Ojasvi Sharma, Jay Yadav, and Anjali Semwal for their project on Crime Scene Reconstruction using AI.
These projects demonstrate SGT University’s commitment to pioneering research that addresses pressing health concerns and advances scientific understanding, underlining the university’s role as a leader in academic and practical innovations.
“We are incredibly proud of our students’ dedication and achievements,” said Dr. Atul Kumar Nasa, Vice-Chancellor of SGT University. “Along with the young scholars, I also congratulate all the teachers and coordinators who have provided immense support to the students in their research pursuits.”
The Scholar’s Council at SGT University continues to play a pivotal role in nurturing the talents and aspirations of its students, preparing them to become future leaders and changemakers in their respective fields.
17, Jul 2024
Understanding Fastener Substitutions in FM-Approved RoofNav Assemblies
Wall, NJ, July 17, 2024 — In the June 2024 issue of Professional Roofing magazine, Mark S. Graham discusses “Fastener Ads” in his article “The Lightning Round.” On page 19, under the section “Fastener Ads,” Graham implies that fastener suppliers have been advertising and directly contacting roof system suppliers, wholesalers, and contractors, offering their fasteners as substitutes for use in specific RoofNav assemblies, even when these fasteners are not FM approved for such applications.
While some fastener suppliers may promote their products as suitable replacements, despite not being FM-approved for specific RoofNav assemblies, Chris McDonald, CEO of Ace Screws, says he hasn’t encountered these ads. He went on to say, “the article did not provide examples of these ads. It would be beneficial to review these articles for a clearer understanding.”
A critical point raised in the article is whether the roofing industry is so uninformed that such practices must be explicitly addressed. Fortunately, organizations like the National Roofing Contractors Association (NRCA) play a vital role in educating industry members. Ace Screws’ observations suggest that contractors approved to install specific manufacturer systems are well aware of the necessity to use properly labeled fasteners, even if it’s for a full system warranty and not strictly an FM RoofNav project.
Manufacturers clearly understand the requirement for FM-approved fasteners for RoofNav projects, and the wholesalers that Ace Screws interacts with are knowledgeable about both manufacturer warranties and the requirements for RoofNav projects. So much so, that Ace Screws is having difficulty understanding the point Graham is attempting to make.
For material manufacturers, Ace Screws offers assistance in getting Ace-labeled FM-approved fasteners through the proper approval process for all your FM RoofNav projects. For wholesalers, Ace provides FM-approved fasteners as private-labeled generics or Ace-labeled fasteners as generics. Given the significant number of low-slope roofs being installed, and considering that Ace prices can be 100, 200, or even 300 percent below what others are charging, partnering with Ace can significantly enhance profits.
Contractors can purchase Ace Screws products directly from Essential Roofing Supply, LLC and other online and physical-location wholesalers, potentially reducing fastener expenses by over half on generic projects.
17, Jul 2024
Dr. Bina Modi Felicitated by Hon’ble Vice President of India for Contributions to SILF
17th July 2024 New Delhi, Delhi, India Dr. Bina Modi, Chairperson and Managing Director of Modi Enterprises – KK Modi Group, was honored by the esteemed Vice President of India, Sh. Jagdeep Dhankar, for her ‘Outstanding Contribution to the Cause of Corporate Social Responsibility’. The event marked the inauguration of the new building for the Society of Indian Law Firms (SILF), with the Vice President gracing the occasion as the chief guest.
Expressing her gratitude for the felicitation, Dr Bina Modi remarked, “I’m truly humbled to receive this recognition from the honorable Vice President of our country. Corporate Social Responsibility has been a way of life for all KK Modi Group companies since long before they became compliant. Leading the CSR initiatives of our group companies, whether it’s uplifting vulnerable farmer communities in Andhra Pradesh or supporting the education of young girls through initiatives like Khushi, brings me immense pleasure and purpose. I see this commitment towards unhindered empowerment of entities in SILF as well.”
Dr. Modi further added, “It is my pleasure to support SILF in their mission and vision of being responsible towards the citizens of our country. I am aligned with their objectives and will continue to extend my support to them in every possible manner.”
Dr. Modi has been actively engaged in various Corporate Social Responsibility initiatives aimed at uplifting communities and fostering sustainable development. Since 2015, she has been supporting the marginalized farmer community in Andhra Pradesh through multifaceted interventions. These initiatives encompass healthcare provisions, access to clean drinking water via RO water plants, ecological balance through extensive plantations and biodiversity parks, and empowerment of farmers through increased training and education on sustainable agricultural practices. Additionally, after-school programs have been implemented to ensure children stay in school and are shielded from child labor. Water conservation efforts, including the construction of check-dams, farm ponds, and de-siltation, have also been prioritized.
Furthermore, Project Khushi, conceived by Dr. Bina Modi, aims to empower rural girls nationwide by sponsoring their education or vocational aspirations. Currently supporting deserving girls in Maharashtra, Project Khushi seeks to extend its reach across other regions.
This recognition adds another feather to Dr. Bina Modi’s hat of being a responsible business leader with accolades like Women Empowerment in Leadership, Outstanding Businesswoman of the Year, Most Inspiring Woman in Business, and Women Transforming India among many others.
17, Jul 2024
Building Trust Through Excellence: The Journey of Prateek Group
17th July 2024 New Delhi, Delhi, India Established in 2005, Prateek Group embarked on its journey with a vision of quality and on-time delivery. Founded by Mr. Prashant Tiwari, a Civil Engineer with a futuristic outlook, the company quickly gained prominence in the real estate sector. With over two decades of experience, Mr. Tiwari envisioned transforming dreams into reality, making homeownership accessible to all.
In a short span, Prateek Group has experienced exponential growth and success, earning a reputation for benchmark quality standards, unwavering values, and transparent business practices. Under the dynamic leadership, the company has become synonymous with trust and excellence, emerging as the preferred real estate name in North India.
Prateek Group stands tall on an 18+ year legacy, driven by a commitment to quality and on-time delivery. It is renowned for its rock-solid values of integrity, customer-centricity, and robust engineering in every aspect of operations. The ethos revolves around nurturing enduring relationships built on trust and a shared vision of a brighter future.
“Prateek Group echoes the sentiment of trust and transparency,” says Prateek Tiwari, the Managing Director, Prateek Group. “Our company is focused on thoughtful planning and flawless execution ensuring every promise made is fulfilled. The dedication to exceeding expectations fosters trust and confidence among stakeholders.”
Delivering on Promises: Projects That Speak Volumes
From Prateek – The Royal Cliff (Crossing Republik, Ghaziabad) to Prateek Edifice (Sector 107, Noida), each project epitomizes the relentless pursuit of excellence. With avant-garde residential developments like Prateek Stylome (Sector 45, Noida) and Prateek Laurel (Sector 120, Noida), the company has set new standards in urban living. Additionally, the integrated township, Prateek Grand City (Siddharth Vihar, Ghaziabad), reflects the commitment to holistic community development. Each project is a preferred choice of discerning buyers, where hundreds and thousands of joyful families reside, and highlights the promise of trust and quality that Prateek Group delivers.
As the company looks ahead, projects like Prateek Grand City (Siddharth Vihar, Ghaziabad) and Prateek Canary (Sector 150, Noida) signify a commitment to innovation and sustainability. With an upsurge in the group’s development, its projects witnessed prices doubling from launch to possession, reflecting their desirability and investment potential. Their properties consistently command high demand and rental rates, cementing their status as premier destinations for shoppers and businesses. Furthermore, the jaw-dropping resale value of Prateek Group’s projects solidifies them as assets of enduring value in the dynamic commercial real estate. By continuously raising the bar, Prateek Group aims to redefine urban living and create spaces that enrich lives.
Recognitions and Accolades: A Testament to Excellence
The pursuit of excellence has garnered recognition from esteemed institutions like NDTV Property Awards and Star Realty Awards. These accolades validate the unwavering dedication to quality, affordability, and innovation. Each award serves as a testament to the relentless commitment to delivering nothing but the best.
Connecting Through CSR: Making a Positive Impact
Prateek Foundation ‘Aakar’, the CSR arm, reflects the commitment to social responsibility. From renovating schools to empowering prison inmates through education, Prateek Group strives to make a positive impact on society. By partnering with NGOs like ‘Help Care Society’ and ‘Children Reading Society,’ the company aims to uplift the underprivileged and build a brighter future for all.
Prateek Group invites every prospective client and stakeholder to experience excellence firsthand. Whether through website exploration or direct engagement, individuals can discover how Prateek Group is shaping the future of real estate. Trust, transparency, and excellence are not just promises; they’re the guiding principles that drive the company forward, every day.
