28, Jul 2026
India’s Warehousing Sector Maintains Growth Momentum Amid Strong Demand
New Delhi, July 28: India’s warehousing sector has continued to show resilience during the January-June period, supported by growing business activity, expanding supply chains, and rising demand for efficient storage solutions, according to a report.
The sector has seen steady interest from industries such as manufacturing, retail, e-commerce, and consumer goods, reflecting the increasing importance of modern warehousing infrastructure in India’s economic growth.
Experts said the stable demand highlights the changing landscape of logistics, with businesses increasingly focusing on faster deliveries, better inventory management, and technology-driven supply chain solutions.
Improved infrastructure, rising investments, and the expansion of organised warehousing facilities have further strengthened the sector’s outlook.
The report noted that India’s warehousing industry is playing a crucial role in supporting trade, strengthening supply chains, and creating new opportunities across various sectors.
With continued economic growth and increasing demand for efficient logistics networks, the warehousing sector is expected to remain an important pillar of India’s development journey.
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- By Neel Achary
28, Jul 2026
IIM Udaipur Celebrates 15 Years of Excellence, Honours Legacy and Looks Ahead to a Global Future
UDAIPUR, India, July 28, 2026 /PRNewswire/ — The Indian Institute of Management Udaipur (IIM Udaipur) marked its 15th Foundation Day with a grand celebration on campus, bringing together distinguished academicians, industry leaders, alumni, faculty, staff, and students to commemorate the Institute’s remarkable journey of academic excellence, research leadership, and global recognition.
The celebration was graced by Prof. Somak Raychaudhury, Vice-Chancellor of Ashoka University, as the Guest of Honour and keynote speaker. Also present were Mr. Pranay Chulet, Founder & CEO of Quikr and Member of the Board of Governors, IIM Udaipur; Prof. Ashok Banerjee, Director, IIM Udaipur; Prof. Vijayta Doshi, Dean – Programs; and Prof. Anirban Adhikary, Dean – Faculty and Research.
Founded on July 27, 2011, IIM Udaipur has rapidly established itself as one of India’s leading management institutions. Today, it is the youngest Indian Institute of Management to receive AACSB accreditation and has consistently featured in the QS World University Rankings and the Financial Times Masters in Management Global Rankings for 7 consecutive years, reflecting its growing international reputation.
Welcoming the gathering, Prof. Vijayta Doshi highlighted the Institute’s commitment to delivering transformative management education while nurturing socially responsible and globally competent leaders. In his Foundation Day address, Prof. Ashok Banerjee reflected on the milestones achieved by the Institute and outlined its vision for the future, emphasising excellence in teaching, impactful research, international collaborations, digital innovation, and stronger engagement with industry and society.
Delivering the Board’s perspective, Mr. Pranay Chulet shared valuable insights on entrepreneurship, innovation, and the evolving business landscape. Encouraging students to embrace curiosity, resilience, and lifelong learning, he spoke about the importance of institutions like IIM Udaipur in shaping leaders capable of creating meaningful impact in an increasingly dynamic world.
A significant highlight of the celebration was the recognition of faculty and staff members who have completed ten years of dedicated service to the Institute. Prof. Arundhati Bhattacharyya, Dr. Arvind Sharma, and Mr. Maredla Uday Bhaskar were felicitated for their long-standing contributions to the Institute’s growth. The ceremony also featured the presentation of the Research Paper Publication Award to Mr. Pramod Kumar, recognising excellence in research and scholarly contribution.
Representing the alumni community, Mr. Kshitij Prabhu, Partner at Cura Capital and an elected member of the IIM Udaipur Alumni Council, addressed the gathering and reflected on the Institute’s growing global alumni network. He reaffirmed the Alumni Council’s commitment to strengthening alumni engagement and mentoring future generations of IIM Udaipur graduates.
Another highlight of the ceremony was the announcement of the Professor of the Year Award by the IIM Udaipur Alumni Council, which recognises excellence in teaching and a lasting impact on the student community. The award was presented to Prof. Rajesh Agrawal, who received the honour for the third consecutive year, reflecting the Institute’s alumni’s deep appreciation and continued admiration for his outstanding contribution to management education.
The keynote address by Prof. Somak Raychaudhury inspired the audience with thought-provoking insights on scientific inquiry, interdisciplinary learning, and the role of higher education in driving innovation and nation-building. Drawing from his distinguished career in astrophysics and academic leadership, he emphasised that institutions must foster curiosity, creativity, and collaboration to address the complex challenges of the future.
Shri Raghuvir Kothi Memorial Scholarship, instituted to support and encourage academic excellence among the children of IIM Udaipur staff members, was continued for the second consecutive year. This scholarship was awarded to Ms. Aanvi Sharma, daughter of Shri Sachin Sharma.
The ceremony concluded with a Vote of Thanks by Prof. Anirban Adhikary, bringing to a close a memorable celebration that honoured IIM Udaipur’s achievements while reaffirming its commitment to shaping responsible leaders, advancing impactful research, and contributing meaningfully to society.
As IIM Udaipur embarks on its sixteenth year, the Institute remains steadfast in its pursuit of excellence, innovation, and global impact, strengthening its position as one of India’s fastest-rising business schools and a hub for transformative management education.
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28, Jul 2026
KuCoin Celebrates Nine Years of Brand and Industry Evolution as the Celestia Stage Transforms at Tomorrowland Belgium Weekend 2
PROVIDENCIALES, Turks and Caicos Islands, July 28, 2026 /PRNewswire/ — KuCoin concluded the second weekend of Tomorrowland Belgium 2026 by marking its ninth anniversary alongside its global partners and community, while celebrating the broader progress of the digital asset industry over the past nine years. The milestone formed part of a memorable weekend that also brought an entirely new lineup of artists to the Celestia Stage and revealed the next chapter of its evolved visual identity, with the butterfly-inspired structure emerging in KuCoin’s signature green. Together, these moments connected KuCoin’s anniversary narrative, Tomorrowland’s creative energy and Celestia’s vision of trust, discovery and transformation.

KuCoin’s ninth anniversary was celebrated through its broader “Beyond the Signal” campaign, which looks beyond short-term market movements toward the trust, innovation and infrastructure enabling the industry’s long-term development. During Weekend 2, KuCoin marked the milestone through the “On Cloud 9 Skybox Experience,” bringing partners and community representatives together to recognize nine years of shared growth and industry progress.
Throughout the weekend, the Celestia Stage offered festivalgoers an entirely new program of artists, including Mark Knight, Mr. Belt & Wezol, Belters Only, Bingo Players with Iceman, Dada Life, Sander van Doorn and Dannic b2b Dyro. From house and progressive sounds to high-energy electronic sets, the performances created a vibrant festival atmosphere, bringing audiences from around the world together through music, movement and shared celebration.
Following its debut during Weekend 1, Celestia returned with an evolved visual identity, transforming from a young butterfly with a transparent roof and subtle touches of KuCoin green as the color gradually spread across its translucent wings, forming vivid emerald patterns while preserving the stage’s light and open character. Shaped by the music, energy and connections shared across both weekends, this evolution symbolized growth, trust and possibility, while reflecting KuCoin’s nine-year journey and the digital asset industry’s broader transformation from an emerging, trading-focused technology into trusted infrastructure increasingly connected to finance, culture and everyday life.
The Celestia Stage brings together the perspectives of KuCoin and Tomorrowland: a belief in the power of imagination, technology and community to connect people across borders. Tomorrowland invites people to explore new worlds through music and creativity, while KuCoin is working to make the future of digital finance more accessible, trusted and human.
As Tomorrowland’s Official Exclusive Crypto Exchange and Crypto Payments Partner for Tomorrowland Winter and Tomorrowland Belgium 2026 – 2028, KuCoin will continue working with Tomorrowland to create meaningful real-world connections. The shared vision remains clear: lasting transformation is built through trust, brought to life through innovation and carried forward by global communities.
About KuCoin
Founded in 2017, KuCoin is a leading global crypto platform built on trust and security, serving over 45 million users across 200+ countries and regions. Known for its reliability and user-first approach, the platform combines advanced technology, deep liquidity, and strong security safeguards to deliver a seamless trading experience. KuCoin provides access to 1,500+ digital assets through a broad product suite and remains committed to building transparent, compliant, and user-centric digital asset infrastructure for the future of finance, backed by SOC 2 Type II, ISO/IEC 27001:2022, and ISO/IEC 27701:2019 Certifications. In recent years, we have built a strong global compliance foundation, marked by key milestones including AUSTRAC registration in Australia, a MiCA license in Europe, and regulatory progress in other markets.
Learn more at www.kucoin.com.
About Tomorrowland
Founded 20 years ago by Belgian brothers Manu and Michiel Beers, Tomorrowland remains a family-owned business driven by a creative and passionate team. Over the years, Tomorrowland has evolved into a global entertainment brand.
The WEAREONE.world group consists of several business units, including Festival & Events, Music, Experiences, Leisure, Products and Fiction. Today, more than 350 team members create magic from the company’s headquarters in Antwerp, Belgium, as well as local offices in Brazil, France, Ibiza and Thailand.
Known for bringing people together through music, creativity and storytelling, Tomorrowland has become one of the world’s most recognized and influential festival brands, inspiring millions through unforgettable experiences and a shared vision of connection.

Photo – https://mma.prnewswire.com/media/3008009/image1.jpg
Logo – https://mma.prnewswire.com/media/2785613/KuCoin_new_Logo.jpg
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28, Jul 2026
Altimetrik Launches Industrial AI Service Line with Three New Solutions for Autonomous Manufacturing
Smart Machines, Smart Plants, and Smart Operations help manufacturers move from isolated AI pilots to production-scale industrial intelligence
BENGALURU, India, July 28, 2026 /PRNewswire/ — Altimetrik, an AI-native engineering company, has introduced an industrial AI service line with three solutions designed to help manufacturers and other enterprises integrate AI directly into machines, factory floors, and supply chain operations.
The three solutions — Smart Machines, Smart Plants, and Smart Operations can operate independently or as part of an integrated system. They enable organizations in the semiconductor, automotive, aerospace, defense, industrial machinery OEM, and pharmaceutical industries, among others, to start with a single machine or use case and expand toward plantwide and enterprise-wide autonomous operations.
“The measure of industrial AI is simple: how much waste does it remove from the line. Less downtime, less scrap, less capital tied up in inventory,” said Raj Sundaresan, CEO of Altimetrik. “This service line takes the engineering discipline of ALTi AIOS™ to the factory floor, and our work with LMW shows what that looks like: AI embedded in the machines themselves, improving accuracy and uptime.”
The industrial AI service line leads with business outcomes and is delivered through three integrated motions: executive advisory, pilot to platform, and strategic transformation. The Smart Machines, Smart Plants, and Smart Operations solutions are designed for OEMs looking to embed AI into their core products, manufacturers optimizing production across machines and lines, and service providers improving performance and reliability for the assets they operate.
That starts with Smart Machines, which transforms equipment into self-aware, adaptive systems through edge-native intelligence. By combining machine connectivity, digital twins, closed-loop optimization, and predictive maintenance, Smart Machines identifies and corrects issues before they disrupt production, reducing downtime and improving equipment performance.
Smart Plants extends those capabilities to the factory floor as a copilot. Through plantwide data integration, OEE and throughput intelligence, and quality prediction systems, Smart Plants enables perception-decision-action autonomy across production lines. The result is zero-touch operations that improve yield and compress cycle times as labor and quality costs decline.
Smart Operations carries AI throughout the broader manufacturing value chain. By applying service and supply chain analytics, Smart Operations strengthens operational resilience and reduces working capital requirements while opening new revenue streams.
“Customers seek AI services firms who tie machine intelligence to plant-wide and enterprise-wide outcomes,” said R “Ray” Wang, the Founder, Chairman and Principal Analyst of Silicon Valley based Constellation Research Inc. “This is the type of pragmatic approach manufacturers need to get past pilots and deliver real results, rather than treating AI as a standalone capability.”
Industrial AI goes beyond analytics, reporting, and automation tools. It perceives, decides, and acts in the physical world, processing machine telemetry and sensor data in real time to make decisions at the edge in milliseconds. Lakshmi Machine Works (LMW) Limited, one of India’s leading engineering conglomerates and a global player in textile machinery and machine tools, recently engaged Altimetrik to embed AI and ML capabilities across its textile and machine tool business.
“In our ongoing engagement with Altimetrik, we remain fully assured of their proven AI-powered automation capabilities to drive tangible value across our global operations through improved machine accuracy and uptime,” said Sanjay Jayavarthanavelu, Chairman and Managing Director at LMW Limited. “This we believe will reduce shop-floor skill dependency thereby accelerating our service responsiveness. We look forward to deepening this partnership as we continue to embed such intelligence across our product portfolio.”
Altimetrik’s industrial AI solutions build on existing physical and operational technology infrastructure rather than requiring manufacturers to replace hardware, sensors, or edge devices. Every engagement operates under the company’s human-at-the-helm philosophy, ensuring operators retain oversight and control as AI assumes greater responsibility within production environments.
Learn more about how Altimetrik helps manufacturers and enterprises scale AI from pilot to production.
About Altimetrik
Altimetrik is an AI-native engineering company helping some of the most revered and iconic enterprises modernize systems, data, and processes at the heart of their business, so they can move faster, operate more efficiently, and innovate continuously. Through ALTi AIOS™, its AI-native operating system, Altimetrik combines the latest AI capabilities with deep engineering expertise to help clients solve complex challenges, accelerate modernization, and deliver measurable outcomes at scale.
Altimetrik’s clients get access to the latest AI innovations while maintaining the flexibility to choose the right technologies for their business, through trusted relationships with OpenAI, Google Gemini, Anthropic, Databricks, and major hyperscalers.
A member of the World Economic Forum’s Centre for AI Excellence, the Forum’s global hub for shaping responsible AI, Altimetrik is also recognized in the 2025 Constellation Research ShortList™ for Global AI Services and named a Major Contender in multiple Everest Group PEAK Matrix® assessments, including Software Product Engineering Services (2026), Enterprise Quality Engineering Services (2025), and Digital Engineering Services for BFSI and Life Sciences. Learn more at altimetrik.com.
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28, Jul 2026
HomeFirst Finance Company India standalone net profit rises 34.45% to Rs 160 cr Q1FY27
MUMBAI, India, July 28, 2026 /PRNewswire/ —
- AUM at ₹16,938 Cr; growth of 25.7% y-o-y and 6.7% q-o-q.
- Disbursal reaches record ₹1,628 Cr, delivering 31.0% y-o-y and 3.6% q-o-q growth.
- Stable Asset Quality maintained in line with Mar’26: 1+ DPD at 4.7%, 30+ DPD at 3.2%, 90+ DPD at 1.8%.
- PAT grows by 34.5% y-o-y and 7.0% q-o-q to ₹160 Cr. RoA at 4.2%
Key Performance
|
Particulars |
Q1FY27 |
Q1FY26 |
y-o-y |
Q4FY26 |
q-o-q |
|
AUM (₹Cr) |
16,938 |
13,479 |
25.7 % |
15,878 |
6.7 % |
|
Disbursement (₹Cr) |
1,628 |
1,243 |
31.0 % |
1,572 |
3.6 % |
|
Total Income (₹Cr) |
540 |
455 |
18.6 % |
505 |
7.0 % |
|
PAT (₹Cr) |
160 |
119 |
34.5 % |
149 |
7.0 % |
|
Spread (%) |
5.3 % |
5.1 % |
+20 bps |
5.3 % |
0 bps |
|
ROA (%) |
4.2 % |
3.7 % |
+50 bps |
4.1 % |
+10 bps |
|
Gross Stage 3 (%) |
1.8 % |
1.8 % |
0 bps |
1.8 % |
0 bps |
|
Cost to Income (%) |
32.7 % |
34.2 % |
-150 bps |
32.0 % |
+70 bps |
Commenting on the performance, Mr. Manoj Viswanathan, MD & CEO of HomeFirst Finance Company, said “As FY27 begins, the Indian economy continues to demonstrate strong resilience, supported by stable domestic consumption, moderating inflation, steady interest rates and improving liquidity. While global geopolitical and macroeconomic uncertainties persist, the outlook for affordable housing finance remains positive, driven by sustained customer demand.
Against this backdrop, HomeFirst delivered a robust start to the year. Assets Under Management (AUM) grew 25.7% year-on-year to ₹16,938 crore, while quarterly disbursements reached a record ₹1,628 crore. Growth was broad-based across geographies and distribution channels, reflecting the strength of the Company’s customer franchise, disciplined execution and continued demand in its target segment.
Financial performance remained strong, with Profit After Tax rising 34.5% year-on-year to ₹160 crore. Net Total Income increased by 29.9% to ₹332 crore, supported by healthy business growth, improving operating leverage and stable asset quality. Margins remained resilient through disciplined pricing and prudent liability management, while spreads stayed stable despite a competitive environment.
The Company continued investing in future growth by expanding its distribution network with four new branches, taking its presence to 175 branches and 373 touchpoints, while adding 133 employees, primarily in customer-facing roles. Asset quality remained stable, with Gross Stage 3 at 1.8% and credit costs contained at 40 basis points, reflecting the strength of HomeFirst’s underwriting and collections framework.
HomeFirst also advanced its sustainability agenda by certifying another 100 Green Homes during the quarter, taking the cumulative total to 550 certified homes. Looking ahead, the Company remains confident of delivering around 25% AUM growth while maintaining profitability, portfolio quality and operating efficiency. Backed by a strong capital position, diversified funding profile and scalable operating platform, HomeFirst believes it is well positioned to create sustainable long-term value for all stakeholders.”
For details, visit https://homefirstindia.com/.
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28, Jul 2026
Some Friendships are as Rare as Natural Diamonds: De Beers Celebrates Friendship Day with ‘Love, from Bestie’ Campaign
MUMBAI, India, July 28, 2026 /PRNewswire/ — Celebrating these lifelong bonds this Friendship Day, De Beers India invites best friends across nine cities to celebrate their shared journey through ‘Love, from Bestie’, a natural diamond ritual created especially for friendship. From 1st to 2nd August, best friend duos can head to 60 retail partner stores, including Forevermark Diamond Jewellery stores, across Mumbai, Delhi, Bengaluru, Chennai, Pune, Kanpur, Kochi, Coimbatore and Nagpur, to discover the collection and take part in a specially curated in-store experience.
At the heart of this initiative is the Bestie Bracelet Collection, featuring four natural diamond designs specifically created to be worn in pairs. These innovative pieces serve as wearable symbols of shared history, including a signature ‘BFF’ design that uses baguette and round diamonds to spell the sentiment in Morse code, as well as interlocking and split-circle motifs that form a complete whole only when brought together. The collection reflects the core philosophy that certain friendships are so inherently natural that only a rare, authentic diamond can truly encapsulate their meaning.
Complimentary for every bestie duo who walks in, the experience unfolds across three simple, joyful stops. It begins with Bond Together, where best friends can pause and unwind with an express nail-art moment. From there, duos move into Create Together, getting hands-on as they build a bag charm for each other, something small and personal to carry the moment forward. The experience closes with Capture Forever, a playful photo op complete with props, followed by the signing of a Bestie Contract that makes their forever-bestie status official. Every pair leaves with a tangible memory of their enduring connection.
Toranj Mehta, Country Head, Category Marketing, De Beers India, said, “The truest friendships cannot be manufactured, they simply unfold naturally. Love from Bestie struck a chord because it gave women a meaningful way to celebrate a relationship that rarely gets its own dedicated occasion: their lifelong friendships. In year 2, De Beers is evolving this sentiment into a proper ritual that consumers can look forward to every Friendship Day. From the intricate designs of the bracelets to the curated experiences we are building at retail, every element is designed to help women mark a bond that is as enduring and real as a natural diamond.”
Best friends can register for the exclusive activation at their nearest store via the dedicated link- https://withlovefrombestie.netlify.app/
For more information & store details, visit www.adiamondisforever.com
About De Beers Group
Established in 1888, De Beers Group is the world’s leading diamond company with expertise in the exploration, mining, marketing and retailing of diamonds. Together with its joint venture partners, De Beers Group is the world’s largest diamond producer by value, with diamond mining operations in Botswana, Canada, Namibia and South Africa. Innovation sits at the heart of De Beers Group’s strategy as it develops a portfolio of offers that span the diamond value chain, including its jewellery houses, De Beers London, Forevermark Diamond Jewellery, and other pioneering solutions such as diamond sourcing and traceability initiatives Tracr and GemFair. De Beers Group also provides leading services and technology to the diamond industry in the form of education and laboratory services and a wide range of diamond sorting, detection and classification technology services. De Beers Group is committed to ‘Building Forever,’ a holistic and integrated approach for creating a better future – where safety, human rights and ethical integrity continue to be paramount; where communities thrive and the environment is protected; and where there are equal opportunities for all. De Beers Group is a member of the Anglo American plc group. For further information, visit www.debeersgroup.com.
Media Contact: debeers@adfactorspr.com
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28, Jul 2026
Ortec Finance selected by Ostrum Asset Management for its GLASS ALM and PRISM Machine-Learning Optimization tools
London | July 28 – Ortec Finance, a leading provider of investment modelling solutions, today announced that Ostrum Asset Management, an expert Insurance and Institutional investment manager and affiliate of Natixis Investment Managers, has selected Ortec Finance’s GLASS ALM and PRISM Machine-Learning Optimization solutions to provide an enhanced investment solutions offering to its insurance and pension clients.
Following an extensive technical evaluation, Ortec Finance’s advanced Strategic Asset Allocation tooling was selected by Ostrum Asset Management to serve as a single and consistent platform for developing tailored investment strategies. The selection reflects growing demand among asset managers for advanced modelling capabilities that support increasingly complex insurance and pension investment challenges.
By leveraging advanced analytics and scenario modeling, Ortec Finance’s solutions will support Ostrum Asset Management investment teams in delivering enhanced investment insights that help insurers and pension funds as they navigate uncertainty and pursue long-term financial objectives.
Ortec Finance’s GLASS platform is industry-leading for Insurance and Pensions ALM. It includes robust capital market assumptions that drive full balance sheet dynamics and the optimization of complex objectives and constraints, such as Solvency ratios and risk capital, with the PRISM scenario-based machine-learning optimizer. Customizable, interactive, analytics dashboards translate detailed results into meaningful insights and illustrate value to stakeholders.
By incorporating advanced tools into their investment solution design, asset managers can offer clients enhanced risk management capabilities to tailor investment strategies to their specific objectives and constraints. The implementation of GLASS as a common platform across both insurance and pension use cases offers methodological consistency and process efficiency while supporting sophisticated investment solution design.
Ortec Finance’s advanced modelling techniques enable users to optimize asset allocation decisions by directly targeting regulatory capital, funding and reporting objectives and constraints, irrespective of the complexity. This allows investment managers the ability to quantitatively evaluate the risks and benefits of alternative investment strategies relative to their risk-return objectives and overall balance sheet positions.
“We are thrilled to have been selected by Ostrum Asset Management to support its investment solutions capabilities,” said Hamish Bailey, Managing Director, at Ortec Finance. “This decision not only illustrates the power and flexibility of the GLASS system, but also its ability to help asset managers serve insurance and pension clients through a single, consistent modelling platform.”
28, Jul 2026
NTPC Posts Strong Q1 Performance, Profit Rises 12 pc on Operational Growth
New Delhi, July 28: Power sector major NTPC Ltd has reported a strong performance in the first quarter, with its profit rising 12 per cent, beating market expectations and reflecting steady growth in its core operations.
The company’s improved earnings were supported by consistent power generation, efficient operations, and continued demand for electricity across the country.
NTPC said the quarterly performance reflects its focus on strengthening India’s energy security while advancing investments in renewable energy, technology upgrades, and sustainable power solutions.
The company continues to expand its clean energy initiatives alongside its conventional power business to meet the country’s growing electricity requirements and support long-term energy transition goals.
Industry experts said the positive results highlight the resilience of the power sector and NTPC’s ability to maintain growth momentum amid changing market conditions.
The strong quarterly performance is expected to reinforce investor confidence and support NTPC’s future expansion plans as the company continues to play a key role in India’s evolving energy landscape.
28, Jul 2026
Study: Casdatifan Demonstrates Durable Tumor Responses in Heavily Pretreated Patients with Advanced Kidney Cancer
MIAMI, July 28: A new multi-center clinical study is shedding light on a potential new approach for patients with advanced kidney cancer, offering measurable clinical responses alongside a clearer view into how the disease operates beneath the surface.
Findings from the ARC-20 phase 1 clinical trial show that casdatifan, an oral investigational therapy designed to inhibit hypoxia-inducible factor-2 alpha, produced durable tumor responses with a manageable safety profile in patients with heavily pretreated clear cell renal cell carcinoma, the most common form of kidney cancer. The study appears in Nature.
For a disease that often adapts and resists treatment, the results provide an early signal that a more targeted approach may help slow its momentum.
“These findings are encouraging and suggest we may be able to better understand which patients benefit from targeting this pathway,” said co-author of the study, Jamie Merchan, M.D., co-leader of the Translational and Clinical Oncology Research Program at Sylvester Comprehensive Cancer Center, part of University of Miami Miller School of Medicine, and director of its Phase 1 Clinical Trials Program.
Clear cell renal cell carcinoma is driven in large part by abnormal activation of HIF-2α, a transcription factor that helps tumors grow, spread and survive in low-oxygen environments.
In many ways, the pathway acts like a control center inside the tumor, switching on signals that fuel its growth. While earlier therapies have attempted to interrupt this process, response rates have remained limited in patients whose disease progresses after initial treatment.
Casdatifan was designed to more effectively interrupt that signal, with characteristics intended to improve how the drug reaches and engages tumor tissue.
The ARC-20 study enrolled 127 patients with advanced, treatment-resistant disease, most of whom had received multiple prior therapies. Among patients receiving the recommended dose, the confirmed objective response rate was 35%. Across the full study population, the response rate was 31%, with more than 80% of patients achieving disease control, including stable disease.
Responses occurred within a median of approximately three months. In some cases, tumors continued to shrink over time rather than plateau early.
“These results are notable in a heavily pretreated population,” said Merchan. “They suggest this approach may provide meaningful activity for patients who have limited options.”
The study was a single-arm, early-phase trial and was not designed to compare casdatifan directly with other therapies. Differences in study design and patient populations also limit cross-trial comparisons.
A defining feature of the study is how closely it connects what is happening in the clinic to what is happening inside the tumor. Researchers observed that reductions in serum erythropoietin, a marker regulated by HIF-2α, were associated with higher response rates, lower rates of disease progression and longer progression-free survival.
Tumor analyses reinforced the pattern. Patients whose tumors showed higher levels of HIF-2α-related activity were more likely to benefit, suggesting the drug is engaging the pathway it was designed to target. Together, these findings begin to map a clearer connection between tumor biology and treatment response, helping researchers see not just whether a therapy works, but why.
“This is an important step in understanding how tumor biology may help guide treatment decisions,” Merchan said.
The safety profile of casdatifan was consistent with other therapies targeting the same pathway. Common side effects included anemia, fatigue and hypoxia, most of which were managed with supportive care and dose adjustments. Treatment discontinuation related to the study drug was infrequent, and no treatment-related deaths were reported.
While the results are encouraging, researchers emphasize that additional studies are needed to better define the role of casdatifan in treating advanced kidney cancer. Ongoing clinical trials are evaluating the therapy in combination with other treatments to determine whether outcomes can be further improved.
Casdatifan remains investigational in this setting and is not yet part of standard treatment.
For now, the ARC-20 study offers a clearer glimpse into how targeting a central cancer pathway may influence outcomes, particularly in tumors that appear to depend on that signal.
“In a disease that can shift and adapt over time, even a clearer line of sight into its underlying biology represents meaningful progress, helping guide where research and treatment strategies move next,” Merchan.
28, Jul 2026
MEI Sector Set for Strong Salary Growth in FY27, Says Report
New Delhi, July 28: Salaries in the MEI (Manufacturing, Engineering and Infrastructure) sector are expected to grow by 9.4 per cent in FY27, reflecting positive business sentiment and continued demand for skilled professionals, according to a report.
The projected salary growth highlights the sector’s steady expansion, driven by increased investments, infrastructure development, and rising demand for specialised talent.
Industry experts said companies are focusing on attracting and retaining skilled employees as competition for experienced professionals continues to increase across key segments.
The report noted that the growth in compensation is expected to be supported by improving business activity, technological advancement, and the need for workforce capabilities in emerging areas.
The positive salary outlook indicates growing opportunities for professionals in the MEI sector and reflects the broader momentum in India’s industrial and infrastructure landscape.